Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.59 |
| ▸ | CA9 | Q16790 | 3/20 | 0.58 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9210328 | 0.89 | CHRNA7 (0.63) | CHRNA7CA9NR1H2PTGS2PTGS1 | |
| SCHEMBL30050028 | 0.85 | NPSR1 (0.51) | CHRNA7CA9NPSR1TP53ALDH1A1 | |
| SCHEMBL30049915 | 0.85 | NPSR1 (0.51) | CHRNA7CA9NPSR1TP53ALDH1A1 | |
| SCHEMBL9210036 | 0.85 | CA9 (0.75) | CHRNA7CA9NR1H2PTGS2FAAH | |
| SCHEMBL23706283 | 0.85 | NPSR1 (0.51) | CHRNA7CA9NPSR1TP53ALDH1A1 | |
| SCHEMBL9207359 | 0.85 | ALDH1A1 (0.58) | ALDH1A1PTGS2PTGS1 | |
| SCHEMBL9208216 | 0.84 | PTGS2 (0.49) | CHRNA7NR1H2ALDH1A1PTGS2PTGS1 | |
| SCHEMBL7627415 | 0.83 | CHRNA7 (0.83) | CHRNA7CA9PTGS2PTGS1 | |
| SCHEMBL9941326 | 0.83 | CA9 (0.82) | CHRNA7CA9NR1H2PTGS2PTGS1 | |
| SCHEMBL7872745 | 0.83 | CHRNA7 (0.66) | CHRNA7CA9NR1H2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |