Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | MARS1 | P56192 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212272 | 0.90 | MARS1 (0.55) | PTGS2PTGS1AOC3CHRNA7MARS1 | |
| SCHEMBL9208216 | 0.88 | PTGS2 (0.49) | PTGS2PTGS1AOC3CHRNA7 | |
| SCHEMBL9199556 | 0.85 | AOC3 (0.65) | PTGS2PTGS1AOC3CHRNA7 | |
| SCHEMBL9210328 | 0.84 | CHRNA7 (0.63) | PTGS2PTGS1AOC3CHRNA7 | |
| SCHEMBL9202142 | 0.83 | PTGS2 (0.52) | PTGS2PTGS1CHRNA7MARS1 | |
| SCHEMBL9202470 | 0.82 | PTGS2 (0.51) | PTGS2PTGS1AOC3CHRNA7 | |
| SCHEMBL8487135 | 0.80 | RXRA (0.48) | PTGS2PTGS1AOC3CHRNA7 | |
| SCHEMBL9744791 | 0.79 | PTGS2 (0.46) | PTGS2CHRNA7 | |
| SCHEMBL9204779 | 0.79 | PTGS2 (0.57) | PTGS2PTGS1AOC3 | |
| SCHEMBL9209551 | 0.78 | ALOX5 (0.60) | PTGS2CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |