Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTK | P29376 | 3/20 | 0.45 |
| ▸ | CDK8 | P49336 | 3/20 | 0.45 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.45 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215680 | 0.90 | PLK3 (0.53) | LTKCDK8PLK3PLK4DAPK3 | |
| SCHEMBL9538373 | 0.76 | PLK1 (0.46) | PLK3PLK1CSNK2A1CCNA2CDK2 | |
| SCHEMBL9535703 | 0.75 | PLK1 (0.61) | PLK3KDRPLK1CSNK2A1DRD4 | |
| Hydrochloric Acid SCHEMBL9534437 | 0.73 | PLK1 (0.59) | PLK3PLK1CSNK2A1DRD4DRD2 | |
| SCHEMBL9219795 | 0.72 | PLK4 (0.41) | LTKCDK8PLK3PLK4DAPK3 | |
| SCHEMBL9211095 | 0.72 | PLK1 (0.49) | CDK8PLK3PLK1CSNK2A1DRD4 | |
| SCHEMBL9218737 | 0.71 | DRD4 (0.48) | LTKCDK8PLK3PLK4DAPK3 | |
| SCHEMBL9534036 | 0.71 | CSNK2A1 (0.35) | PLK3PIM1AURKAPLK1CSNK2A1 | |
| SCHEMBL9533488 | 0.70 | PLK1 (0.34) | PLK3PLK1CSNK2A1 | |
| SCHEMBL9218064 | 0.70 | PLK1 (0.34) | PLK3PLK1CSNK2A1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276833-B1 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMA (US) | 1995-02-15 | — | — | EP | claimed |
| EP-0276833-A2 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | claimed |
| US-4734430-A | Dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | claimed |
| EP-0276833-B1 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMA (US) | 1995-02-15 | — | — | EP | disclosed |
| EP-0276833-A2 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734430-A | Dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |