Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | LTK | P29376 | 2/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.41 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9211969 | 0.88 | LTK (0.49) | PLK4DAPK3PIM1PDGFRALTK | |
| SCHEMBL9221036 | 0.77 | TSHR (0.41) | RECQLTSHRKMT2AKDM4EHSD17B10 | |
| SCHEMBL9220188 | 0.76 | AADAT (0.47) | RECQLTSHRKMT2AALDH1A1LMNA | |
| SCHEMBL9219418 | 0.75 | TSHR (0.40) | RECQLTSHRALDH1A1LMNAKDM4E | |
| SCHEMBL6791823 | 0.73 | IKBKB (0.43) | AURKAALDH1A1LMNAHPGDAADAT | |
| SCHEMBL9210952 | 0.72 | LTK (0.45) | PLK4DAPK3PIM1PDGFRALTK | |
| SCHEMBL6663384 | 0.70 | ELANE (0.55) | PLK3RECQLTSHRKMT2ALMNA | |
| SCHEMBL20439112 | 0.70 | SMN1; SMN2 (0.46) | RECQLTSHRALDH1A1LMNAKDM4E | |
| SCHEMBL9222643 | 0.68 | AADAT (0.44) | TDO2RECQLTSHRALDH1A1LMNA | |
| SCHEMBL9222639 | 0.68 | AADAT (0.44) | TDO2RECQLTSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276833-B1 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMA (US) | 1995-02-15 | — | — | EP | disclosed |
| EP-0276833-A2 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734430-A | Dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |