Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 7/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | RPA1 | P27694 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9202142 | 0.90 | PTGS2 (0.52) | MARS1MEN1KMT2AATMPTGS2 | |
| SCHEMBL9205210 | 0.85 | CHRNA7 (0.54) | MARS1PTGS2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9204658 | 0.84 | KMT2A (0.72) | MARS1MEN1KMT2AATMPTGS2 | |
| SCHEMBL9204760 | 0.84 | KMT2A (0.72) | MARS1MEN1KMT2AATMPTGS2 | |
| SCHEMBL16876785 | 0.83 | MARS1 (0.57) | MARS1MEN1KMT2AATMRPA1 | |
| SCHEMBL9212272 | 0.83 | MARS1 (0.55) | MARS1MEN1KMT2AATMPTGS2 | |
| SCHEMBL9200861 | 0.81 | SCN9A (0.45) | MARS1MEN1KMT2AATMPTGS2 | |
| SCHEMBL27694774 | 0.78 | KMT2A (0.69) | MARS1MEN1KMT2AATMRPA1 | |
| SCHEMBL9202425 | 0.78 | PTGS2 (0.48) | PTGS2L3MBTL1 | |
| SCHEMBL23024350 | 0.77 | L3MBTL1 (0.51) | MARS1MEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |