Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | MARS1 | P56192 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | RPA1 | P27694 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9200861 | 0.91 | SCN9A (0.45) | PTGS2MARS1MEN1KMT2AATM | |
| SCHEMBL9211018 | 0.90 | MARS1 (0.56) | PTGS2MARS1MEN1KMT2AATM | |
| SCHEMBL9203885 | 0.87 | PTGS2 (0.47) | PTGS2MARS1MEN1KMT2ASCN9A | |
| SCHEMBL9200442 | 0.85 | PTGS2 (0.45) | PTGS2MARS1MEN1KMT2AATM | |
| SCHEMBL9199551 | 0.85 | MEN1 (0.56) | PTGS2MEN1KMT2AATMCHRNA7 | |
| SCHEMBL9209766 | 0.85 | MEN1 (0.56) | PTGS2MEN1KMT2AATMCHRNA7 | |
| SCHEMBL9205210 | 0.84 | CHRNA7 (0.54) | PTGS2MARS1CHRNA7CNR1CNR2 | |
| SCHEMBL9208779 | 0.83 | PTGS2 (0.51) | PTGS2MARS1CHRNA7PTGS1 | |
| SCHEMBL9207624 | 0.78 | MARS1 (0.49) | MARS1MEN1KMT2ASCN9AL3MBTL1 | |
| SCHEMBL9201469 | 0.77 | ALDH1A1 (0.43) | PTGS2MARS1MEN1KMT2ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |