Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2143931 | 0.76 | GAA (0.45) | ALOX5MEN1KMT2AMAPTGAA | |
| SCHEMBL28517190 | 0.73 | PDGFRA (0.35) | MEN1KMT2ABRD4CREBBPMAPT | |
| SCHEMBL29699894 | 0.71 | NTSR1 (0.33) | KDM4E | |
| SCHEMBL3667230 | 0.68 | ALOX5 (0.47) | ALOX5MEN1KMT2ABRD4CREBBP | |
| SCHEMBL1724752 | 0.68 | ALOX5 (0.43) | ALOX5MEN1KMT2ABRD4CREBBP | |
| SCHEMBL10969348 | 0.65 | HTR5A (0.41) | MEN1KMT2ABRD4CREBBPMAPT | |
| Phenoxazine SCHEMBL29355714 | 0.64 | ALOX5 (1.00) | ALOX5MEN1KMT2APARP1MAPT | |
| Phenoxazine SCHEMBL28844098 | 0.64 | ALOX5 (1.00) | ALOX5MEN1KMT2APARP1MAPT | |
| Phenoxazine SCHEMBL6310178 | 0.64 | ALOX5 (1.00) | ALOX5MEN1KMT2APARP1MAPT | |
| Phenoxazine SCHEMBL7862 | 0.64 | ALOX5 (1.00) | ALOX5MEN1KMT2APARP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664810-A1 | 3,3-DISUBSTITUTED TRI- AND TETRACYCLIC INDOLIN-2-ONES USEFUL FOR THE TREATMENT OF COGNITIVE DISORDERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-08-02 | — | — | EP | disclosed |