Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | RPA1 | P27694 | 3/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | MARS1 | P56192 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208216 | 0.90 | PTGS2 (0.49) | ALDH1A1MAPTHTTPTGS2PTGS1 | |
| SCHEMBL9212272 | 0.87 | MARS1 (0.55) | ALDH1A1MEN1KMT2APTGS2RPA1 | |
| SCHEMBL27694774 | 0.85 | KMT2A (0.69) | ALDH1A1MAPTHTTMEN1KMT2A | |
| SCHEMBL9211545 | 0.85 | CHRNA7 (0.59) | ALDH1A1PTGS2PTGS1 | |
| SCHEMBL9199654 | 0.84 | RPA1 (0.72) | MEN1KMT2APTGS2RPA1MARS1 | |
| SCHEMBL9203245 | 0.81 | MEN1 (0.70) | MEN1KMT2APTGS2RPA1PTGS1 | |
| SCHEMBL9210302 | 0.81 | RPA1 (0.57) | MEN1KMT2APTGS2RPA1PTGS1 | |
| SCHEMBL8953900 | 0.80 | PTGS2 (0.53) | ALDH1A1PTGS2PTGS1 | |
| SCHEMBL9203418 | 0.79 | PTGS2 (0.53) | PTGS2PTGS1ALOX5 | |
| SCHEMBL9208779 | 0.77 | PTGS2 (0.51) | PTGS2PTGS1MARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046506-C | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-11-17 | — | — | CN | disclosed |
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |