Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14309113 | 0.89 | SRC (0.42) | NPSR1KMT2ACHEK1TSHRHTT | |
| SCHEMBL2045175 | 0.72 | — | — | |
| SCHEMBL30346383 | 0.72 | SRC (0.49) | NPSR1KMT2ACHEK1TSHRHTT | |
| SCHEMBL3542410 | 0.71 | NPSR1 (0.49) | NPSR1KMT2ACHEK1TSHRHTT | |
| SCHEMBL2624085 | 0.71 | TSHR (0.49) | NPSR1KMT2ACHEK1TSHRHTT | |
| Hydrochloric Acid SCHEMBL3933886 | 0.71 | UHRF1 (0.35) | UHRF1OR51E2NNMTLMNA | |
| SCHEMBL13577565 | 0.70 | ALDH1A1 (0.36) | NPSR1KMT2ACHEK1TSHRHTT | |
| SCHEMBL30538678 | 0.70 | UHRF1 (0.37) | UHRF1NNMT | |
| SCHEMBL1747901 | 0.70 | UHRF1 (0.37) | UHRF1NNMT | |
| SCHEMBL12349970 | 0.69 | GAA (0.50) | NPSR1KMT2ACHEK1TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255228-B1 | 4(3H)-OXO-5,6,7,8,-TETRAHYDROPYRIDO-(2,3-D)PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-05-02 | — | — | EP | claimed |
| US-4833145-A | 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-23 | — | — | US | claimed |
| EP-0255228-A1 | 4(3H)-Oxo-5,6,7,8,-Tetrahydropyrido-(2,3-d)Pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1988-02-03 | — | — | EP | claimed |
| JP-63033379-A | — | — | None | — | — | JP | disclosed |
| US-7632839-B2 | Mitotic kinesin inhibitors | MERCK & CO. INC. (US) | 2009-12-15 | — | — | US | disclosed |
| US-7632839-B2 | Mitotic kinesin inhibitors | MERCK & CO. INC. (US) | 2009-12-15 | — | — | US | disclosed |
| US-20080139586-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2008-06-12 | — | — | US | disclosed |
| US-20080139586-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2008-06-12 | — | — | US | disclosed |
| EP-0344922-B1 | N-(N-(tetrahydropyrido(2,3-d)pyrimidinylmethyl)-aminomethylbenzoyl)glutamic acid derivatives | UNIV PRINCETON (US) | 1995-10-18 | — | — | EP | disclosed |
| CN-1014895-B | Process for preparation of 4(3H)-oxo-5,6,7,8-tetrahydropyrido-[2,3-d] pyrimidine derivatives | UNIV PRINCETON (US) | 1991-11-27 | — | — | CN | disclosed |
| CN-1014895-B | Process for preparation of 4(3H)-oxo-5,6,7,8-tetrahydropyrido-[2,3-d] pyrimidine derivatives | UNIV PRINCETON (US) | 1991-11-27 | — | — | CN | disclosed |
| EP-0255228-B1 | 4(3H)-OXO-5,6,7,8,-TETRAHYDROPYRIDO-(2,3-D)PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-05-02 | — | — | EP | disclosed |
| EP-0255228-B1 | 4(3H)-OXO-5,6,7,8,-TETRAHYDROPYRIDO-(2,3-D)PYRIMIDINE DERIVATIVES | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-05-02 | — | — | EP | disclosed |
| US-4833145-A | 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-23 | — | — | US | disclosed |
| US-4833145-A | 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-23 | — | — | US | disclosed |
| US-4831037-A | 4 (3H)-oxo-5,6,7,8-tetrahydropyrido-(2,3-d)pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-16 | — | — | US | disclosed |
| JP-S6333379-A | 4(3H)-OXO-5,6,7,8-TETRAHYDROPYRIDO(2,3-D)PYRIMIDINE DERIVATIVE | UNIV PRINCETON | 1988-02-13 | — | — | JP | disclosed |
| EP-0255228-A1 | 4(3H)-Oxo-5,6,7,8,-Tetrahydropyrido-(2,3-d)Pyrimidine derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1988-02-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139586-A1 | Mitotic Kinesin Inhibitors | KIF5B, KIF2C, KIFC1 | NPSR1 4514/4885KMT2A 454/4885CHEK1 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.