Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.40 |
| ▸ | PIM1 | P11309 | 5/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM5A | P29375 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9205154 | 0.74 | KDM5A (0.54) | KDM4EALDH1A1HPGDHSD17B10HSP90AA1 | |
| SCHEMBL5826398 | 0.71 | NPY1R (0.45) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL9215707 | 0.69 | DPP4 (0.34) | KDM4EALDH1A1HPGDHSD17B10HSP90AA1 | |
| SCHEMBL31278019 | 0.69 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10NTRK1 | |
| SCHEMBL5444601 | 0.69 | HPGD (0.54) | KDM4EALDH1A1HPGDHSD17B10HSP90AA1 | |
| SCHEMBL5827369 | 0.68 | CRHR1 (0.45) | MAPT | |
| SCHEMBL5450178 | 0.68 | HPGD (0.53) | KDM4EALDH1A1HPGDHSD17B10HSP90AA1 | |
| SCHEMBL9213889 | 0.68 | GSK3B (0.36) | KDM4EALDH1A1HPGDHSD17B10HSP90AA1 | |
| SCHEMBL5826658 | 0.67 | CRHR1 (0.44) | — | |
| SCHEMBL8207281 | 0.67 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369145-B1 | Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives and medicines comprising the same | POLA CHEM IND INC (JP) | 1995-12-27 | — | — | EP | disclosed |
| US-4992442-A | Bronchodilator agents | POLA CHEMICAL INDUSTRIES INC., JAPAN (JP) | 1991-02-12 | — | — | US | disclosed |
| EP-0369145-A2 | Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives and medicines comprising the same | POLA CHEMICAL INDUSTRIES INC., JAPAN (JP) | 1990-05-23 | — | — | EP | disclosed |