Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 2/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212136 | 1.00 | MGAM (0.48) | MGAMKDM4EKMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL9209728 | 0.74 | MGAM (0.57) | MGAMKDM4EKMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL1765966 | 0.73 | MGAM (0.65) | MGAMKDM4ECYP1A2BCAT1HPGDS | |
| SCHEMBL3455076 | 0.73 | POLB (0.52) | KMT2ASMN1; SMN2MAPTHTTNPC1 | |
| SCHEMBL3455077 | 0.73 | POLB (0.52) | KMT2ASMN1; SMN2MAPTHTTNPC1 | |
| SCHEMBL29505143 | 0.73 | ALOX15 (0.65) | MGAMKDM4EKMT2ASMN1; SMN2BCAT1 | |
| SCHEMBL2031896 | 0.73 | ALOX15 (0.65) | MGAMKDM4EKMT2ASMN1; SMN2BCAT1 | |
| SCHEMBL9214530 | 0.73 | RAB9A (0.54) | MGAMKDM4EKMT2ASMN1; SMN2MEN1 | |
| Acetonitrile SCHEMBL9903188 | 0.71 | MGAM (0.81) | MGAMKDM4EKMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL9211506 | 0.70 | HSD17B10 (0.42) | MGAMKDM4EKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | disclosed |
| US-5272164-A | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-12-21 | — | — | US | disclosed |
| US-5223508-A | Hypotensive agents, vasodilators | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5166347-A | Hypotensive agents, cardiovascular disorders, antiischemic agents and anticoagulants | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0388528-A2 | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1990-09-26 | — | — | EP | disclosed |