Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE6D | O43924 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE6A | P16499 | 1/20 | 0.39 |
| ▸ | PDE6G | P18545 | 1/20 | 0.39 |
| ▸ | PDE6B | P35913 | 1/20 | 0.39 |
| ▸ | PDE6C | P51160 | 1/20 | 0.39 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9213666 | 0.94 | PDE6D (0.37) | PDE6DPDE5APDE6APDE6GPDE6B | |
| Hydrochloric Acid SCHEMBL9213791 | 0.92 | ACHE (0.37) | PDE6DPDE5APDE6APDE6GPDE6B | |
| SCHEMBL9213603 | 0.88 | GRM5 (0.38) | PDE6DPDE5APDE6APDE6GPDE6B | |
| Hydrochloric Acid SCHEMBL9215725 | 0.87 | GRM5 (0.38) | PDE6DPDE5APDE6APDE6GPDE6B | |
| SCHEMBL9215978 | 0.86 | PDE5A (0.39) | PDE6DPDE5APDE6APDE6GPDE6B | |
| SCHEMBL9213558 | 0.82 | ACHE (0.42) | PDE5AMEN1USP2ALDH1A1POLB | |
| SCHEMBL9216543 | 0.81 | LTA4H (0.39) | PDE6DPDE5APDE6APDE6GPDE6B | |
| Hydrochloric Acid SCHEMBL9213433 | 0.80 | ACHE (0.41) | PDE5AMEN1USP2ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL9739565 | 0.80 | LTA4H (0.38) | PDE6DPDE5APDE6APDE6GPDE6B | |
| Hydrochloric Acid SCHEMBL9210506 | 0.79 | CHRNB4 (0.45) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |