Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9741229 | 0.80 | RAB9A (0.51) | MEN1MAPK1KMT2ATDP1RAB9A | |
| SCHEMBL9217121 | 0.79 | HRH3 (0.56) | HRH3KCNH2MAPTPOLB | |
| SCHEMBL9278988 | 0.79 | HRH3 (0.48) | HRH3KCNH2 | |
| SCHEMBL9217118 | 0.79 | DRD2 (0.49) | HRH3KCNH2MEN1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9738996 | 0.78 | HRH3 (0.48) | HRH3KCNH2MEN1CYP1A2CYP3A4 | |
| SCHEMBL9206438 | 0.78 | HRH3 (0.64) | HRH3TSHRKMT2A | |
| SCHEMBL9215679 | 0.78 | KDM4E (0.67) | HRH3TSHRKMT2A | |
| SCHEMBL7398551 | 0.78 | HRH3 (0.73) | HRH3KCNH2MEN1CYP1A2CYP3A4 | |
| SCHEMBL9699038 | 0.77 | MAOB (0.49) | HRH3KCNH2MEN1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL9528708 | 0.77 | RAB9A (0.50) | HRH3KCNH2MEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |