Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9206438 | 0.89 | HRH3 (0.64) | KDM4EL3MBTL1HRH3ALDH1A1TSHR | |
| SCHEMBL11983507 | 0.81 | KDM4E (1.00) | KDM4EL3MBTL1HRH3ALDH1A1TSHR | |
| SCHEMBL9217121 | 0.81 | HRH3 (0.56) | HRH3 | |
| SCHEMBL9278988 | 0.81 | HRH3 (0.48) | HRH3 | |
| SCHEMBL9212860 | 0.78 | HRH3 (0.57) | HRH3TSHRKMT2A | |
| SCHEMBL12660177 | 0.78 | KDM4E (0.91) | KDM4EL3MBTL1HRH3ALDH1A1TSHR | |
| SCHEMBL9211609 | 0.77 | KDM4E (0.55) | KDM4EL3MBTL1HRH3ALDH1A1KMT2A | |
| SCHEMBL21621022 | 0.77 | KDM4E (0.64) | KDM4EL3MBTL1HRH3 | |
| SCHEMBL8361480 | 0.76 | KDM4E (0.83) | KDM4EL3MBTL1ALDH1A1TSHR | |
| SCHEMBL8691213 | 0.75 | LTA4H (0.55) | KDM4EHRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |