Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9206438 | 0.88 | HRH3 (0.64) | HRH3 | |
| SCHEMBL9278988 | 0.87 | HRH3 (0.48) | HRH3KCNH2 | |
| SCHEMBL9205104 | 0.84 | HRH3 (0.65) | HRH3 | |
| SCHEMBL9215679 | 0.81 | KDM4E (0.67) | HRH3 | |
| SCHEMBL10648187 | 0.80 | DPP4 (0.44) | HRH3POLBMAPTCHRNB2CHRNB4 | |
| SCHEMBL9212860 | 0.79 | HRH3 (0.57) | HRH3POLBMAPTKCNH2 | |
| SCHEMBL8691213 | 0.76 | LTA4H (0.55) | HRH3LTA4H | |
| SCHEMBL4099964 | 0.76 | HRH3 (0.84) | HRH3POLBMAPTKCNH2 | |
| Hydrochloric Acid SCHEMBL8690326 | 0.75 | LTA4H (0.54) | HRH3LTA4H | |
| SCHEMBL9739552 | 0.75 | CHRNB2 (0.57) | HRH3POLBMAPTKCNH2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |