Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.38 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9221753 | 0.91 | KDM4E (0.54) | KDM4EALDH1A1SMN1; SMN2EPHA2KMT2A | |
| SCHEMBL9211090 | 0.91 | KDM4E (0.54) | KDM4EALDH1A1SMN1; SMN2EPHA2KMT2A | |
| SCHEMBL9214327 | 0.86 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL9213959 | 0.84 | EPHA2 (0.48) | KDM4EALDH1A1EPHA2KMT2AHPGD | |
| SCHEMBL28851224 | 0.75 | EPHA2 (0.51) | ALDH1A1EPHA2ERBB2EPHB4GLA | |
| SCHEMBL9209696 | 0.75 | HTR2A (0.47) | KDM4EALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL9213710 | 0.73 | EPHA2 (0.49) | KDM4EALDH1A1EPHA2KMT2AHSD17B10 | |
| SCHEMBL9211866 | 0.73 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL306369 | 0.73 | EPHA2 (0.50) | KDM4EEPHA2HPGDERBB2EPHB4 | |
| Fumaric Acid SCHEMBL9209066 | 0.73 | HTR2A (0.41) | KDM4EALDH1A1SMN1; SMN2KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411912-B1 | Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders | SANKYO CO (JP) | 1995-04-19 | — | — | EP | disclosed |
| EP-0411912-A2 | Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders | Sankyo Company Limited (JP) | 1991-02-06 | — | — | EP | disclosed |