Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9205660 | 0.93 | GRM5 (0.42) | KDM4EITGB3ITGA2BGRM5CYP2D6 | |
| SCHEMBL9213734 | 0.92 | GRM5 (0.41) | KDM4EITGB3ITGA2BGRM5CYP2D6 | |
| SCHEMBL9740217 | 0.84 | ITGB3 (0.39) | ITGB3ITGA2BGRM5CYP2D6AOC3 | |
| SCHEMBL9208356 | 0.82 | GRM5 (0.42) | ITGB3ITGA2BGRM5AOC3CDK9 | |
| SCHEMBL9207883 | 0.81 | NAAA (0.40) | KDM4EITGB3ITGA2BCYP2D6 | |
| SCHEMBL9740567 | 0.80 | DRD2 (0.41) | KDM4EGRM5CYP2D6CDK9 | |
| SCHEMBL9209711 | 0.79 | MEN1 (0.50) | KDM4EITGB3ITGA2BGRM5 | |
| SCHEMBL9207567 | 0.79 | DRD2 (0.39) | KDM4EGRM5CYP2D6CDK9 | |
| SCHEMBL30420984 | 0.78 | GRM5 (0.48) | ITGB3ITGA2BGRM5AOC3CDK9 | |
| SCHEMBL9208151 | 0.75 | GRM5 (0.44) | ITGB3ITGA2BGRM5CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |