Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.30 |
| ▸ | TEK | Q02763 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9221777 | 0.90 | PLK1 (0.49) | PLK1CSNK2A1PLK3DRD2DRD4 | |
| SCHEMBL9535703 | 0.73 | PLK1 (0.61) | PLK1CSNK2A1PLK3DRD2DRD4 | |
| SCHEMBL9215792 | 0.72 | CCNA2 (0.43) | DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL9534437 | 0.71 | PLK1 (0.59) | PLK1CSNK2A1PLK3DRD2DRD4 | |
| SCHEMBL9211138 | 0.71 | PLK1 (0.44) | PLK1CSNK2A1PLK3DRD2DRD4 | |
| SCHEMBL9210952 | 0.71 | LTK (0.45) | PLK1CSNK2A1PLK3DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL9219786 | 0.70 | PLK1 (0.42) | PLK1CSNK2A1PLK3DRD2DRD4 | |
| SCHEMBL9211170 | 0.68 | PLK1 (0.44) | PLK1CSNK2A1PLK3DRD2DRD4 | |
| SCHEMBL9538373 | 0.67 | PLK1 (0.46) | PLK1CSNK2A1PLK3 | |
| SCHEMBL6790531 | 0.66 | CCNA2 (0.60) | PLK1CSNK2A1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276833-B1 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMA (US) | 1995-02-15 | — | — | EP | claimed |
| EP-0276833-A2 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | claimed |
| US-4734430-A | Dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | claimed |
| EP-0276833-B1 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMA (US) | 1995-02-15 | — | — | EP | disclosed |
| EP-0276833-A2 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734430-A | Dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |