Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17895066 | 0.91 | SLC6A1 (0.44) | MAPTPKMTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL8224141 | 0.89 | MAPT (0.49) | MAPTPKMTSHRALDH1A1 | |
| SCHEMBL2235927 | 0.89 | MAPT (0.49) | MAPTPKMTSHRALDH1A1 | |
| SCHEMBL12994147 | 0.89 | MAPT (0.49) | MAPTPKMTSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL3902332 | 0.87 | MAPT (0.51) | MAPTPKMALDH1A1 | |
| Hydrochloric Acid SCHEMBL29447270 | 0.87 | MAPT (0.51) | MAPTPKMALDH1A1 | |
| Hydrochloric Acid SCHEMBL30448400 | 0.87 | MAPT (0.51) | MAPTPKMALDH1A1 | |
| SCHEMBL10582025 | 0.86 | CHRNB2 (0.37) | TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL6063290 | 0.82 | PPM1B (0.41) | MAPTPKMTSHRSMN1; SMN2 | |
| SCHEMBL3002273 | 0.80 | GNAI3 (0.42) | MAPTPKMTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5470859-A | Cognition activators for the central nervous system | BEECHAM GROUP P.L.C. (GB) | 1995-11-28 | — | — | US | disclosed |
| EP-0414394-B1 | Azabicyclic Derivatives having muscarinic receptor affinity | BEECHAM GROUP PLC (GB) | 1995-07-05 | — | — | EP | disclosed |
| US-5217975-A | AZABICYCLIC COMPOUNDS FOR TREATING DEMENTIA | BEECHAM GROUP P.L.C. (GB) | 1993-06-08 | — | — | US | disclosed |
| EP-0414394-A2 | Azabicyclic Derivatives having muscarinic receptor affinity | BEECHAM GROUP PLC (GB) | 1991-02-27 | — | — | EP | disclosed |
| EP-0402056-A2 | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them | Beecham Group p.l.c. (GB) | 1990-12-12 | — | — | EP | disclosed |