Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | AGER | Q15109 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212721 | 0.98 | MEN1 (0.60) | MEN1KMT2ALMNAKDM4EALOX15 | |
| SCHEMBL9374910 | 0.98 | MEN1 (0.60) | MEN1KMT2ALMNAKDM4EALOX15 | |
| SCHEMBL9295749 | 0.89 | LMNA (0.48) | MEN1KMT2ALMNAKDM4EALOX15 | |
| SCHEMBL9209690 | 0.89 | LMNA (0.48) | MEN1KMT2ALMNAKDM4EALOX15 | |
| SCHEMBL8361113 | 0.84 | LMNA (0.77) | MEN1KMT2ALMNAKDM4EALOX15 | |
| SCHEMBL10453095 | 0.83 | LMNA (0.62) | MEN1KMT2ALMNAKDM4EALOX15 | |
| SCHEMBL8119724 | 0.83 | ALDH1A1 (0.54) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL9584980 | 0.81 | MEN1 (0.68) | MEN1KMT2ALMNAKDM4EALOX15 | |
| SCHEMBL9542160 | 0.79 | MEN1 (0.71) | MEN1KMT2ALMNAKDM4EALOX15 | |
| SCHEMBL9208637 | 0.79 | SLC6A9 (0.44) | MEN1KMT2ALMNAKDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0404797-B1 | 1H/3H-[4-(N,N-CYCLOALKYL AND/OR BRANCHED-ALKYLCARBOXAMIDO) -BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS | SEARLE & CO (US) | 1995-02-01 | — | — | EP | disclosed |
| EP-0404797-A4 | 1H/3H- 4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL)IMIDAZO 4,5-C)PYRIDINES AS PAF ANTAGONISTS | — | 1992-01-22 | — | — | EP | disclosed |
| EP-0404797-A1 | 1H/3H- 4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO 4,5-c]PYRIDINES AS PAF ANTAGONISTS. | SEARLE & CO (US) | 1991-01-02 | — | — | EP | disclosed |
| WO-1989008653-A1 | 1H/3H-[4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS | G.D. SEARLE & CO. (US) | 1989-09-21 | — | — | WO | disclosed |