Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9295749 | 0.92 | LMNA (0.48) | LMNAMEN1KMT2AKDM4EALOX15 | |
| SCHEMBL9215422 | 0.89 | MEN1 (0.58) | LMNAMEN1KMT2AKDM4EALOX15 | |
| SCHEMBL9212721 | 0.87 | MEN1 (0.60) | LMNAMEN1KMT2AKDM4EALOX15 | |
| SCHEMBL9374910 | 0.87 | MEN1 (0.60) | LMNAMEN1KMT2AKDM4EALOX15 | |
| SCHEMBL9295543 | 0.82 | TRPM8 (0.40) | LMNAMAPTHTTNPSR1HSD11B1 | |
| SCHEMBL8119724 | 0.76 | ALDH1A1 (0.54) | LMNAMEN1KMT2AMAPTHTT | |
| SCHEMBL8361113 | 0.74 | LMNA (0.77) | LMNAMEN1KMT2AKDM4EALOX15 | |
| SCHEMBL10453095 | 0.74 | LMNA (0.62) | LMNAMEN1KMT2AKDM4EALOX15 | |
| SCHEMBL9208637 | 0.73 | SLC6A9 (0.44) | LMNAMEN1KMT2AKDM4EALOX15 | |
| SCHEMBL9584980 | 0.72 | MEN1 (0.68) | LMNAMEN1KMT2AKDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0404797-B1 | 1H/3H-[4-(N,N-CYCLOALKYL AND/OR BRANCHED-ALKYLCARBOXAMIDO) -BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS | SEARLE & CO (US) | 1995-02-01 | — | — | EP | disclosed |
| EP-0404797-A4 | 1H/3H- 4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL)IMIDAZO 4,5-C)PYRIDINES AS PAF ANTAGONISTS | — | 1992-01-22 | — | — | EP | disclosed |
| EP-0404797-A1 | 1H/3H- 4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO 4,5-c]PYRIDINES AS PAF ANTAGONISTS. | SEARLE & CO (US) | 1991-01-02 | — | — | EP | disclosed |
| WO-1989008653-A1 | 1H/3H-[4-(N,N-DICYCLOALKYL/BRANCHED-ALKYLCARBOXAMIDO)-BENZYL]IMIDAZO[4,5-c]PYRIDINES AS PAF ANTAGONISTS | G.D. SEARLE & CO. (US) | 1989-09-21 | — | — | WO | disclosed |