Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CD44 | P16070 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24293395 | 0.81 | TDP1 (0.44) | NR4A2ALDH1A1MAPK1SMN1; SMN2CD44 | |
| SCHEMBL30151434 | 0.81 | TDP1 (0.44) | NR4A2ALDH1A1MAPK1SMN1; SMN2CD44 | |
| SCHEMBL15894463 | 0.76 | NR4A2 (0.46) | NR4A2NCF1POLBNOS3NOS1 | |
| SCHEMBL29672030 | 0.76 | NR4A2 (0.46) | NR4A2NCF1POLBNOS3NOS1 | |
| SCHEMBL19047126 | 0.75 | NCF1 (0.43) | NR4A2NCF1POLBNOS3NOS1 | |
| SCHEMBL9383607 | 0.75 | NCF1 (0.43) | NR4A2NCF1POLBNOS3NOS1 | |
| SCHEMBL21516636 | 0.75 | ALDH1A1 (0.43) | NR4A2POLBALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL28251597 | 0.75 | LMNA (0.42) | NR4A2POLBALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL26521320 | 0.74 | NR4A2 (0.41) | NR4A2NCF1NOS3NOS1NOS2 | |
| SCHEMBL31042951 | 0.73 | NR4A2 (0.43) | NR4A2NCF1POLBNOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112724134-B | Azaindazole bipyridine derivative myeloid cell proliferation inhibitor, preparation method and application thereof in pharmacy | 复旦大学 | 2022-04-01 | — | — | CN | disclosed |
| CN-113214247-A | Azaindole derivative marrow cell proliferation inhibitor, preparation method and application thereof in pharmacy | 复旦大学 | 2021-08-06 | — | — | CN | disclosed |
| CN-112876456-A | Cinnoline compound PI3K kinase inhibitor, preparation method thereof and application thereof in pharmacy | 复旦大学 | 2021-06-01 | — | — | CN | disclosed |
| CN-112724134-A | Azaindazole bipyridine derivative myeloid cell proliferation inhibitor, preparation method and application thereof in pharmacy | 复旦大学 | 2021-04-30 | — | — | CN | disclosed |
| EP-0520724-B1 | Angiotensin II antagonists | ZENECA LTD (GB) | 1995-09-20 | — | — | EP | disclosed |
| US-5387592-A | Angiotensin converting enzyme inhibitors, calcium channel blockers, diuretics and adrenergic blocking agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-02-07 | — | — | US | disclosed |
| EP-0520723-B1 | Angiotensin II antagonists | ICI PLC (GB) | 1994-06-01 | — | — | EP | disclosed |
| US-5281613-A | Heterocyclic ring substituted benzofuran, benzothiofuran, or indole derivative | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-25 | — | — | US | disclosed |
| US-5236937-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| EP-0520723-A1 | Angiotensin II antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-12-30 | — | — | EP | disclosed |
| EP-0520724-A1 | Angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |
| US-4668675-A | ANTIDEPRESSANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-05-26 | — | — | US | disclosed |
| US-4556667-A | (2-((AMINOPYRIDINYL)AMINO)PHENYL)ARYLMETHANONE INTERMEDIATES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-12-03 | — | — | US | disclosed |
| US-4495183-A | ANTIULCER AGENTS- GASTROLINTESTINAL DISORDERS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-01-22 | — | — | US | disclosed |
| US-4447361-A | ANTIDEPRESSANT | A. H. ROBINS COMPANY, INC. (US) | 1984-05-08 | — | — | US | disclosed |