Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740303 | 0.91 | HRH3 (0.60) | KDM4EHRH3ALDH1A1KMT2ACHRNB2 | |
| SCHEMBL9739220 | 0.86 | HRH3 (0.52) | KDM4EHRH3ALDH1A1KMT2ADRD3 | |
| SCHEMBL9739552 | 0.86 | CHRNB2 (0.57) | KDM4EHRH3ALDH1A1KMT2AHRH2 | |
| SCHEMBL9740276 | 0.80 | HTR1A (0.52) | KDM4EL3MBTL1HTR1AHTR7HRH3 | |
| SCHEMBL9208504 | 0.80 | HRH2 (0.49) | KDM4EHRH3ALDH1A1KMT2AHRH2 | |
| SCHEMBL9205099 | 0.79 | HRH3 (0.48) | KDM4EHRH3ALDH1A1KMT2ADRD4 | |
| SCHEMBL9210505 | 0.79 | HRH3 (0.57) | KDM4EHRH3ALDH1A1KMT2ACHRNB2 | |
| SCHEMBL9215679 | 0.77 | KDM4E (0.67) | KDM4EL3MBTL1HRH3ALDH1A1KMT2A | |
| SCHEMBL9212384 | 0.74 | ADRA1A (0.52) | KDM4EHTR1AHTR7ALDH1A1KMT2A | |
| SCHEMBL9205156 | 0.74 | CHRNB2 (0.54) | KDM4EHRH3ALDH1A1KMT2ACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |