Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 5/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216989 | 0.99 | HTR1A (0.36) | HTR1ALTA4HALDH1A1CHRNA7UTS2R | |
| SCHEMBL9206684 | 0.94 | HTR1A (0.41) | HTR1ALTA4HALDH1A1CHRNA7UTS2R | |
| SCHEMBL9215793 | 0.92 | HTR1A (0.39) | HTR1ALTA4HALDH1A1CHRNA7UTS2R | |
| SCHEMBL9215411 | 0.91 | HTR1A (0.38) | HTR1ACHRNA7UTS2RHTR7CRHBP | |
| SCHEMBL9214402 | 0.90 | HTR1A (0.37) | HTR1ACHRNA7UTS2RHTR7CRHBP | |
| SCHEMBL9207407 | 0.89 | HTR1A (0.37) | HTR1ACHRNA7HTR7CRHBPCRHR2 | |
| SCHEMBL9210593 | 0.89 | HCN4 (0.40) | HTR1ASMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL9214709 | 0.88 | HCN4 (0.41) | HTR1ASMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL9216877 | 0.85 | ACHE (0.35) | HTR1APRMT5WDR77CHRNB2CHRNA4 | |
| SCHEMBL9208761 | 0.85 | NPC1 (0.35) | HTR1ALTA4HALDH1A1HTR7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |