Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216452 | 0.96 | MEN1 (0.36) | ACHEMAOBMEN1KMT2AESR1 | |
| SCHEMBL9216931 | 0.92 | ACHE (0.36) | ACHEMAOBMAOAMEN1KMT2A | |
| SCHEMBL9210183 | 0.92 | HCN4 (0.40) | HTR1ACHRNB2CHRNA4MAPTHCN4 | |
| SCHEMBL9206867 | 0.90 | MTNR1A (0.39) | MEN1KMT2AHTR1AMCHR1ADRA1A | |
| SCHEMBL9205646 | 0.88 | MEN1 (0.40) | ACHEMAOBMAOAMEN1KMT2A | |
| SCHEMBL9205217 | 0.88 | HCN4 (0.40) | MAOBMAOAMEN1KMT2AHTR1A | |
| SCHEMBL9214365 | 0.86 | HCN4 (0.40) | HTR1ACHRNB2CHRNA4MAPTHCN4 | |
| SCHEMBL9216989 | 0.86 | HTR1A (0.36) | MEN1KMT2AHTR1APRMT5WDR77 | |
| SCHEMBL9215741 | 0.85 | HTR1A (0.38) | MEN1KMT2AHTR1APRMT5WDR77 | |
| SCHEMBL9215882 | 0.84 | LTA4H (0.32) | MEN1KMT2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |