Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212465 | 0.92 | HDAC1 (0.54) | TP53HDAC1HDAC2L3MBTL1ALDH1A1 | |
| SCHEMBL9219835 | 0.90 | TP53 (0.53) | TP53HDAC1HDAC2ALDH1A1NPC1 | |
| SCHEMBL9212386 | 0.89 | L3MBTL1 (0.52) | TP53HDAC1HDAC2L3MBTL1ALDH1A1 | |
| SCHEMBL9431631 | 0.89 | L3MBTL1 (0.52) | TP53HDAC1HDAC2L3MBTL1ALDH1A1 | |
| SCHEMBL9222006 | 0.88 | HDAC1 (0.51) | TP53HDAC1HDAC2L3MBTL1ALDH1A1 | |
| SCHEMBL9430225 | 0.87 | NPC1 (0.50) | TP53HDAC1HDAC2L3MBTL1ALDH1A1 | |
| SCHEMBL9220337 | 0.87 | L3MBTL1 (0.49) | TP53HDAC1HDAC2L3MBTL1ALDH1A1 | |
| SCHEMBL9215682 | 0.85 | HDAC1 (0.47) | TP53HDAC1HDAC2NPC1RAB9A | |
| SCHEMBL9210110 | 0.84 | HDAC1 (0.56) | HDAC1HDAC2L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9431228 | 0.84 | NPC1 (0.51) | TP53L3MBTL1ALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |