Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | NAAA | Q02083 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212465 | 0.91 | HDAC1 (0.54) | TP53HDAC1HDAC2NAAANPC1 | |
| SCHEMBL9216012 | 0.90 | TP53 (0.55) | TP53HDAC1HDAC2NAAANPC1 | |
| SCHEMBL9220873 | 0.89 | EPHX1 (0.49) | HDAC1HDAC2NAAAALDH1A1EPHX1 | |
| SCHEMBL9215682 | 0.88 | HDAC1 (0.47) | TP53HDAC1HDAC2NAAACNR1 | |
| SCHEMBL9218736 | 0.87 | NAAA (0.47) | TP53MDM2HDAC1HDAC2NAAA | |
| SCHEMBL9219544 | 0.86 | TP53 (0.50) | TP53MDM2CNR1NPC1RAB9A | |
| SCHEMBL9430499 | 0.86 | TP53 (0.50) | TP53MDM2CNR1NPC1RAB9A | |
| SCHEMBL9213682 | 0.86 | TP53 (0.50) | TP53MDM2CNR1NPC1RAB9A | |
| SCHEMBL9209883 | 0.85 | TP53 (0.47) | TP53MDM2HDAC1HDAC2CNR1 | |
| SCHEMBL9218047 | 0.85 | TP53 (0.51) | TP53MDM2CNR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |