Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9215814 | 0.98 | PDE4B (0.48) | PDE4BADRA1BPDE4DACHEHTR1A | |
| SCHEMBL9208530 | 0.91 | BCHE (0.50) | PDE4DACHEDRD4GRM5MAOB | |
| Hydrochloric Acid SCHEMBL9211501 | 0.88 | ALDH1A1 (0.49) | ADRA1BACHEMEN1KMT2AMAOA | |
| SCHEMBL9207082 | 0.87 | BCHE (0.48) | PDE4DACHEDRD4GRM5MAOB | |
| SCHEMBL9215461 | 0.85 | BCHE (0.56) | PDE4DACHEDRD4MAOB | |
| SCHEMBL9739479 | 0.82 | ADRA1B (0.46) | ADRA1BACHEHTR1ADRD4DRD3 | |
| SCHEMBL9208347 | 0.81 | ADRA1B (0.48) | ADRA1BMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10644273 | 0.81 | PDE4B (0.66) | PDE4BKMT2A | |
| Hydrochloric Acid SCHEMBL9214600 | 0.81 | ADRA1B (0.47) | ADRA1BMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9214568 | 0.80 | PDE4B (0.64) | PDE4BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |