Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 3/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215744 | 0.95 | KDM2B (0.37) | KDM2BPDE2ALMNAHCRTR1HCRTR2 | |
| SCHEMBL9216928 | 0.91 | HCRTR1 (0.41) | KDM2BLMNAHCRTR1HCRTR2KCNH2 | |
| SCHEMBL9206763 | 0.90 | LTA4H (0.36) | KDM2BPDE2ALMNACHRM3HCRTR1 | |
| SCHEMBL9213551 | 0.86 | HCRTR1 (0.42) | KDM2BLMNAHCRTR1HCRTR2CHRNA7 | |
| SCHEMBL9213547 | 0.85 | LTA4H (0.37) | KDM2BPDE2ALMNAHCRTR1HCRTR2 | |
| SCHEMBL9214809 | 0.83 | MAPK1 (0.41) | PDE2ALMNAHCRTR1HCRTR2HRH3 | |
| SCHEMBL9208876 | 0.82 | HRH3 (0.36) | LMNAHRH3LTA4HHTR7KCNH2 | |
| SCHEMBL9206641 | 0.82 | MAPK1 (0.41) | PDE2ALMNAHRH3HTR7DRD2 | |
| SCHEMBL9212975 | 0.82 | HRH3 (0.35) | LMNAHRH3LTA4HHTR7KCNH2 | |
| SCHEMBL9215152 | 0.82 | MAPK1 (0.44) | PDE2ALMNAHCRTR1HCRTR2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |