Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 3/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9213547 | 0.95 | LTA4H (0.37) | LTA4HKDM2BLMNAHCRTR1HCRTR2 | |
| SCHEMBL9216368 | 0.90 | KDM2B (0.36) | LTA4HKDM2BLMNAHCRTR1HCRTR2 | |
| SCHEMBL9216928 | 0.88 | HCRTR1 (0.41) | KDM2BLMNAHCRTR1HCRTR2 | |
| SCHEMBL9215744 | 0.85 | KDM2B (0.37) | LTA4HKDM2BLMNAHCRTR1HCRTR2 | |
| SCHEMBL9208812 | 0.83 | DRD2 (0.38) | LTA4HLMNAALDH1A1HTR7DRD2 | |
| SCHEMBL9213551 | 0.83 | HCRTR1 (0.42) | KDM2BLMNAHCRTR1HCRTR2CHRNA7 | |
| SCHEMBL9206564 | 0.83 | NPC1 (0.36) | LTA4HLMNAHRH3ALDH1A1KDM4E | |
| SCHEMBL9209357 | 0.83 | DRD2 (0.37) | LTA4HLMNAHRH3ALDH1A1HTR7 | |
| SCHEMBL9216989 | 0.83 | HTR1A (0.36) | LTA4HLMNAPDE2ACHRNA7ALDH1A1 | |
| SCHEMBL9208761 | 0.82 | NPC1 (0.35) | LTA4HLMNAHRH3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |