SCHEMBL921664

SCHEMBL921664

Nc1ncccc1C(=O)NCc1ccc(Oc2ccc(OC(F)(F)F)c(F)c2)cc1

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 2/20 0.47
MAPK8 P45983 1/20 0.45
KMT2A Q03164 1/20 0.43
SCN3A Q9NY46 1/20 0.43
EGLN1 Q9GZT9 1/20 0.43
HDAC6 Q9UBN7 1/20 0.42
LMNA P02545 1/20 0.42
HPGD P15428 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HTR2C P28335 1/20 0.42
MAPK14 Q16539 1/20 0.42
PPARG P37231 1/20 0.42
PPARD Q03181 1/20 0.42
PPARA Q07869 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL920185 0.93 PPARG (0.51) P2RX7KMT2AHPGDMAPK14PPARG
SCHEMBL920035 0.93 MAPK8 (0.45) P2RX7MAPK8KMT2AEGLN1HDAC6
SCHEMBL921412 0.93 MAPK8 (0.45) P2RX7MAPK8KMT2ASCN3AEGLN1
SCHEMBL921976 0.88 MAPK8 (0.52) MAPK8KMT2AEGLN1HDAC6LMNA
SCHEMBL921833 0.87 MAPK14 (0.54) MAPK8EGLN1HTR2CMAPK14PPARG
SCHEMBL921381 0.87 MAPK8 (0.52) MAPK8KMT2AEGLN1HDAC6LMNA
SCHEMBL919923 0.87 MAPK8 (0.45) MAPK8KMT2AEGLN1HDAC6LMNA
SCHEMBL922737 0.87 MAPK8 (0.47) MAPK8KMT2AHDAC6LMNAHPGD
SCHEMBL922154 0.86 PPARG (0.52) MAPK8KMT2AHPGDHTR2CMAPK14
SCHEMBL920966 0.86 MAPK8 (0.46) MAPK8KMT2AEGLN1HDAC6LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 P2RX7 3935/4885MAPK8 2313/4885KMT2A 2469/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.