SCHEMBL922737

SCHEMBL922737

Nc1ncccc1C(=O)NCc1ccc(Oc2ccc(C(F)(F)F)c(F)c2)cc1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 1/20 0.47
HDAC6 Q9UBN7 1/20 0.46
HCRTR1 O43613 1/20 0.45
HCRTR2 O43614 1/20 0.45
MAPK14 Q16539 1/20 0.44
KMT2A Q03164 1/20 0.44
LMNA P02545 1/20 0.44
HPGD P15428 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL921954 0.92 HPGD (0.47) MAPK8HCRTR1HCRTR2MAPK14KMT2A
SCHEMBL920883 0.92 RPS6KB1 (0.47) MAPK8HDAC6MAPK14KMT2ALMNA
SCHEMBL921664 0.87 P2RX7 (0.47) MAPK8HDAC6MAPK14KMT2ALMNA
SCHEMBL920722 0.86 MAPK14 (0.61) MAPK8HDAC6MAPK14LMNAHPGD
SCHEMBL919622 0.85 MAPK14 (0.54) MAPK8HDAC6MAPK14KMT2A
SCHEMBL921417 0.85 MAPK14 (0.43) HCRTR1HCRTR2MAPK14
SCHEMBL921412 0.85 MAPK8 (0.45) MAPK8HDAC6MAPK14KMT2ALMNA
SCHEMBL920885 0.85 HPGD (0.47) MAPK8MAPK14KMT2AHPGD
SCHEMBL920343 0.84 KMT2A (0.61) MAPK8MAPK14KMT2ALMNAHPGD
SCHEMBL920612 0.84 MAPK8 (0.48) MAPK8MAPK14KMT2ALMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 MAPK8 2313/4885HDAC6 401/4885HCRTR1 3850/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.