Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.37 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9206975 | 0.88 | ALDH1A1 (0.35) | HRH3TRPV6DRD2DRD4 | |
| SCHEMBL9208020 | 0.83 | HCN4 (0.49) | HRH3TRPV6 | |
| Hydrochloric Acid SCHEMBL9739344 | 0.82 | CYP3A4 (0.49) | HRH3TRPV6 | |
| Hydrochloric Acid SCHEMBL9207084 | 0.81 | ADRA1B (0.39) | DRD4 | |
| Hydrochloric Acid SCHEMBL9206844 | 0.81 | CYP3A4 (0.47) | DRD4 | |
| Hydrochloric Acid SCHEMBL9212120 | 0.78 | DRD4 (0.42) | HRH3DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL9739509 | 0.76 | CYP3A4 (0.49) | HRH3 | |
| Hydrochloric Acid SCHEMBL9739342 | 0.73 | CYP3A4 (0.49) | — | |
| SCHEMBL11737839 | 0.73 | SIGMAR1 (0.48) | HRH3TRPV6SIGMAR1 | |
| SCHEMBL9217265 | 0.72 | DRD4 (0.43) | HRH3DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |