Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL520733 | 0.83 | MEN1 (0.58) | MEN1KMT2AMAOBMAOASMN1; SMN2 | |
| SCHEMBL15272040 | 0.82 | SIGMAR1 (0.62) | SIGMAR1OPRK1MAOBMAOAACHE | |
| SCHEMBL27546572 | 0.82 | PYCR1 (0.60) | MEN1KMT2AMAOBMAOAACHE | |
| SCHEMBL4446274 | 0.81 | SIGMAR1 (0.58) | SIGMAR1OPRK1MAOBMAOAACHE | |
| SCHEMBL10533234 | 0.81 | CYP2D6 (0.62) | MEN1KMT2AMAOBMAOAACHE | |
| SCHEMBL30537979 | 0.81 | SIGMAR1 (0.58) | SIGMAR1OPRK1MAOBMAOAACHE | |
| SCHEMBL12310918 | 0.81 | ALDH1A1 (0.52) | MEN1KMT2ASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL2111020 | 0.77 | KMT2A (0.65) | SIGMAR1MEN1KMT2AMAOBMAOA | |
| SCHEMBL7640869 | 0.76 | TSHR (0.54) | SIGMAR1MEN1KMT2AMAOBMAOA | |
| SCHEMBL5461014 | 0.76 | SIGMAR1 (0.56) | SIGMAR1OPRK1SMN1; SMN2ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549039-B1 | 3-Phenylureido-1,4-Benzodiazepinones and their use as cholecystokinin or gastrin antagonists | MERCK SHARP & DOHME (GB) | 1995-08-09 | — | — | EP | disclosed |
| US-5410049-A | Gastrin and cholecystokinin inhibitor | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-25 | — | — | US | disclosed |
| EP-0549039-A1 | 3-Phenylureido-1,4-Benzodiazepinones and their use as cholecystokinin or gastrin antagonists | MERCK SHARP & DOHME LTD. (GB) | 1993-06-30 | — | — | EP | disclosed |