SCHEMBL520733

SCHEMBL520733

COC(=O)Cc1cccc([N+](=O)[O-])c1

nearest known ligand 0.58

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.58
KMT2A Q03164 4/20 0.58
TSHR P16473 1/20 0.56
ALDH1A1 P00352 3/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
MAOB P27338 2/20 0.53
MAOA P21397 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
RECQL P46063 1/20 0.53
RAB9A P51151 1/20 0.52
HTT P42858 1/20 0.52
SLC7A5 Q01650 1/20 0.51
MAPT P10636 2/20 0.51
L3MBTL1 Q9Y468 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16412780 0.87 TSHR (0.56) MEN1KMT2ATSHRALDH1A1SMN1; SMN2
SCHEMBL2111020 0.86 KMT2A (0.65) MEN1KMT2ATSHRALDH1A1MAOB
SCHEMBL28336064 0.86 TSHR (0.54) MEN1KMT2ATSHRALDH1A1SMN1; SMN2
SCHEMBL27424330 0.86 TSHR (0.58) MEN1KMT2ATSHRALDH1A1SMN1; SMN2
SCHEMBL7640869 0.86 TSHR (0.54) MEN1KMT2ATSHRALDH1A1SMN1; SMN2
SCHEMBL9210392 0.86 RAB9A (0.55) MEN1KMT2ATSHRALDH1A1SMN1; SMN2
SCHEMBL28547278 0.85 MAOB (0.70) MEN1KMT2AALDH1A1MAOBMAOA
SCHEMBL6676703 0.85 MAPT (0.55) MEN1KMT2ATSHRALDH1A1SMN1; SMN2
SCHEMBL10936594 0.84 MEN1 (0.63) MEN1KMT2ATSHRALDH1A1MAOB
SCHEMBL9217552 0.83 SIGMAR1 (0.60) MEN1KMT2ATSHRALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4743082-A1 CARBAZOLE COMPOUNDS AND THEIR USE IN THERAPY, IN THE TREATMENT OF A RESPIRATORY INFECTION UCL Business Ltd (GB) 2026-05-20 EP disclosed
US-20260008770-A1 CBL-B INHIBITORS AND METHODS OF USES THEREOF INSILICO MEDICINE IP LTD (HK) 2026-01-08 US disclosed
US-20250388593-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR MITSUBISHI TANABE PHARMA CORPORATION (JP) 2025-12-25 US disclosed
US-20250375428-A1 CBL-B INHIBITORS AND ANTI-PD1/ANTI-PD-L1 FOR USE IN THE TREATMENT OF CANCER HOTSPOT THERAPEUTICS INC (US) 2025-12-11 US disclosed
EP-4650348-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR Mitsubishi Tanabe Pharma Corporation (JP) 2025-11-19 EP disclosed
US-20250340552-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISORDERS HOTSPOT THERAPEUTICS INC (US) 2025-11-06 US disclosed
EP-4637749-A2 CBL-B MODULATORS AND USES THEREOF Nimbus Clio, Inc. (US) 2025-10-29 EP disclosed
US-20250161278-A1 CBL-B INHIBITOR, COMPOSITIONS COMPRISING A CBL-B INHIBITOR IN A METHOD OF TREATING A DISEASE ASSOCIATED WITH CELL PROLIFERATION HOTSPOT THERAPEUTICS, INC. 2025-05-22 US disclosed
EP-4554586-A1 CBL-B INHIBITORS AND ANTI-PD1/ANTI-PD-L1 FOR USE IN THE TREATMENT OF CANCER Hotspot Therapeutics, Inc. (US) 2025-05-21 EP disclosed
EP-4554582-A1 CBL-B INHIBITOR, COMPOSITIONS COMPRISING A CBL-B INHIBITOR IN A METHOD OF TREATING A DISEASE ASSOCIATED WITH CELL PROLIFERATION Hotspot Therapeutics, Inc. (US) 2025-05-21 EP disclosed
EP-1140828-A1 3-AZABICYCLO[3.1.0]HEXANE DERIVATIVES AS OPIATE RECEPTORS LIGANDS Pfizer Limited (GB) 2001-10-10 EP disclosed
CN-1307567-A 1,5 benzodiazepine derivatives ZERIA PHARM CO LTD (JP) 2001-08-08 CN disclosed
EP-1085014-A1 1,5-BENZODIAZEPINE DERIVATIVES Zeria Pharmaceutical Co., Ltd. (JP) 2001-03-21 EP disclosed
WO-2000058293-A2 GLUCOKINASE ACTIVATORS F. HOFFMANN-LA ROCHE AG (CH) 2000-10-05 WO disclosed
WO-2000039089-A1 3-AZABICYCLO[3.1.0.] HEXANE DERIVATIVES AS OPIATE RECEPTORS LIGANDS PFIZER LIMITED (GB) 2000-07-06 WO disclosed
CN-1232452-A NMDA (N-methyl-D-aspartate) antagonists HOECHST MARION ROUSSEL INC (US) 1999-10-20 CN disclosed
US-5633270-A Thiazolidine derivatives, preparation thereof and drugs containing samem RHONE-POULENC RORER S.A. (FR) 1997-05-27 US disclosed
US-5610144-A CHOLECYSTOKININ OR GASTRIN ANTAGONISTS; NERVOUS SYSTEM AND GASTROINTESTINAL DISORDERS RHONE-POULENC RORER S.A. (FR) 1997-03-11 US disclosed
US-4288364-A REACTING A 3-/2-HYDROXYIMINOACETYLAMINO/-2-OXOAZETIDINE WITH AN ORGANIC CARBONATE OR ACYL HALIDE CIBA-GEIGY CORPORATION (US) 1981-09-08 US disclosed
EP-0005507-A1 Process for the fragmentation of 3-(2-hydroxyimino-acetylamino)-2-oxo azetidin compounds and compounds obtained thereby CIBA-GEIGY AG (CH) 1979-11-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250340552-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISORDERS CYP27A1, PNLIP, GOT2 MEN1 436/4885KMT2A 2857/4885TSHR 4612/4885
US-20260008770-A1 CBL-B INHIBITORS AND METHODS OF USES THEREOF CBL, CBLC, CBLB MEN1 4166/4885KMT2A 2417/4885TSHR 939/4885
US-20250161278-A1 CBL-B INHIBITOR, COMPOSITIONS COMPRISING A CBL-B INHIBITOR IN A METHOD OF TREATING A DISEASE ASSOCIATED WITH CELL PROLIFERATION CBLB, CBL, CBLC MEN1 2263/4885KMT2A 1529/4885TSHR 3883/4885
US-20250388593-A1 CEREBLON E3 LIGASE BINDING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PRODUCTION METHOD THEREFOR CRBN, CUL1, CBL MEN1 859/4885KMT2A 663/4885TSHR 2934/4885
US-20250375428-A1 CBL-B INHIBITORS AND ANTI-PD1/ANTI-PD-L1 FOR USE IN THE TREATMENT OF CANCER CBLB, CBL, CBLC MEN1 3610/4885KMT2A 961/4885TSHR 3232/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.