SCHEMBL9219964

SCHEMBL9219964

CCOC(=O)c1ccc(OCCC2CC3CCC(C2)N3c2ccc(Cl)nn2)cc1

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.40
HRH3 Q9Y5N1 1/20 0.40
TBXAS1 P24557 1/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
LMNA P02545 1/20 0.39
KDM4E B2RXH2 1/20 0.38
MAPT P10636 3/20 0.37
RAB9A P51151 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CHRNB2 P17787 1/20 0.36
CHRNA7 P36544 1/20 0.36
CHRNA4 P43681 1/20 0.36
KMT2A Q03164 1/20 0.36
POLB P06746 2/20 0.35
TSHR P16473 1/20 0.35
PKM P14618 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9219673 0.81 NPC1 (0.43) KCNH2HRH3TBXAS1L3MBTL1TDP1
SCHEMBL9220790 0.80 MEN1 (0.47) KCNH2HRH3TBXAS1L3MBTL1TDP1
SCHEMBL10588330 0.77 MEN1 (0.49) KCNH2HRH3LMNAKDM4EMAPT
SCHEMBL10588331 0.77 MEN1 (0.49) KCNH2HRH3LMNAKDM4EMAPT
Pirodavir SCHEMBL146440 0.75 HRH3 (0.46) KCNH2HRH3TBXAS1L3MBTL1TDP1
SCHEMBL9214586 0.75 LMNA (0.46) L3MBTL1LMNACHRNB2CHRNA7CHRNA4
SCHEMBL9197768 0.75 HRH3 (0.53) KCNH2HRH3TBXAS1L3MBTL1LMNA
SCHEMBL1751840 0.74 KCNH2 (0.43) KCNH2HRH3TBXAS1L3MBTL1TDP1
SCHEMBL9212796 0.74 PIK3CA (0.44) KCNH2HRH3TBXAS1L3MBTL1TDP1
SCHEMBL15004872 0.74 HRH3 (0.60) KCNH2HRH3TBXAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0320032-B1 Pyridizinamine derivatives JANSSEN PHARMACEUTICA NV (BE) 1995-01-18 EP disclosed
US-5231184-A Viricide intermediate JANSSEN PHARMACEUTICA N.V. (BE) 1993-07-27 US disclosed
US-5106973-A Viricide intermediates JANSSEN PHARMACEUTICA N.V. (BE) 1992-04-21 US disclosed
US-4992433-A Viricides JANSSEN PHARMACEUTICA N.V. (BE) 1991-02-12 US disclosed
EP-0320032-A1 Pyridizinamine derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1989-06-14 EP disclosed