Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL10435474 | 0.81 | NPC1 (0.46) | GSRALDH1A1KDM4ENPC1TSHR | |
| Nitric Acid SCHEMBL9218571 | 0.74 | ALDH1A1 (0.42) | ALDH1A1KDM4ENPC1CA12CA1 | |
| SCHEMBL334438 | 0.73 | ALDH1A1 (0.68) | ALDH1A1LOXL2KDM4ENPC1CA12 | |
| SCHEMBL7150447 | 0.73 | ALDH1A1 (0.68) | ALDH1A1LOXL2KDM4ENPC1CA12 | |
| SCHEMBL4942727 | 0.73 | ALDH1A1 (0.68) | ALDH1A1LOXL2KDM4ENPC1CA12 | |
| SCHEMBL8204965 | 0.72 | LOXL2 (0.55) | ALDH1A1LOXL2IDO1KDM4ECA12 | |
| Hydrochloric Acid SCHEMBL26098210 | 0.71 | ALDH1A1 (0.66) | ALDH1A1LOXL2KDM4ENPC1CA12 | |
| SCHEMBL18833848 | 0.71 | LOXL2 (0.53) | ALDH1A1LOXL2IDO1KDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL10687747 | 0.71 | LOXL2 (0.53) | ALDH1A1LOXL2IDO1KDM4ECA12 | |
| SCHEMBL942066 | 0.71 | LOXL2 (0.53) | ALDH1A1LOXL2IDO1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388528-B1 | Carboximidamide derivatives | KIRIN BREWERY (JP) | 1995-09-27 | — | — | EP | disclosed |
| US-5272164-A | Carboximidamide derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-12-21 | — | — | US | disclosed |
| US-5223508-A | Hypotensive agents, vasodilators | KIRIN BEER KABUSHIKI KAISHA (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5166347-A | Hypotensive agents, cardiovascular disorders, antiischemic agents and anticoagulants | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-11-24 | — | — | US | disclosed |