Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3489281 | 0.79 | NR3C1 (0.46) | ALDH1A1NR3C1NR3C2CYP3A4PGR | |
| SCHEMBL3490788 | 0.76 | CA1 (0.45) | ALDH1A1NR3C1NR3C2CYP3A4PGR | |
| SCHEMBL15420133 | 0.75 | ABCB1 (0.47) | ALDH1A1ABCB1TDP1GAASMN1; SMN2 | |
| SCHEMBL3490280 | 0.74 | NR3C1 (0.42) | ALDH1A1NR3C1NR3C2CYP3A4PGR | |
| SCHEMBL3489059 | 0.72 | CYP3A4 (0.47) | NR3C1NR3C2CYP3A4PGRTDP1 | |
| SCHEMBL9220640 | 0.72 | NR3C1 (0.42) | ALDH1A1NR3C1NR3C2CYP3A4PGR | |
| SCHEMBL3490267 | 0.72 | CYP3A4 (0.47) | NR3C1NR3C2CYP3A4PGRTDP1 | |
| SCHEMBL3821657 | 0.72 | THRB (0.41) | ALDH1A1LMNAGAASMN1; SMN2PKM | |
| SCHEMBL3488631 | 0.71 | KMT2A (0.52) | ALDH1A1NR3C1NR3C2CYP3A4PGR | |
| SCHEMBL3489898 | 0.71 | NR3C1 (0.44) | NR3C1NR3C2CYP3A4PGRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636124-A1 | 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021170-A1 | 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1993-10-28 | — | — | WO | disclosed |