Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 7/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.42 |
| ▸ | PGR | P06401 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9275311 | 0.88 | TP53 (0.41) | NR3C1NR3C2PGRLMNAHTT | |
| SCHEMBL3488631 | 0.88 | KMT2A (0.52) | NR3C1NR3C2PGRLMNAHTT | |
| SCHEMBL3490967 | 0.87 | CYP19A1 (0.49) | NR3C1NR3C2PGRLMNACYP3A4 | |
| SCHEMBL3489037 | 0.84 | L3MBTL1 (0.41) | NR3C1NR3C2PGRLMNACYP3A4 | |
| SCHEMBL3489075 | 0.83 | ALDH1A1 (0.52) | NR3C1NR3C2PGRLMNAALDH1A1 | |
| SCHEMBL9221541 | 0.83 | ACLY (0.40) | NR3C1NR3C2PGRLMNACYP3A4 | |
| SCHEMBL3491178 | 0.82 | LMNA (0.52) | NR3C1NR3C2PGRLMNACYP3A4 | |
| SCHEMBL3489110 | 0.81 | ALDH1A1 (0.44) | NR3C1NR3C2PGRLMNACYP3A4 | |
| SCHEMBL3489635 | 0.80 | CYP19A1 (0.43) | NR3C1NR3C2PGRLMNACYP3A4 | |
| SCHEMBL3488618 | 0.80 | NSD2 (0.50) | NR3C1NR3C2PGRLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636124-A1 | 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021170-A1 | 3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE-3-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1993-10-28 | — | — | WO | disclosed |