SCHEMBL9220176

SCHEMBL9220176

FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)CC(Cl)c1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9225482 0.98 TSHR (0.37) TSHR
SCHEMBL9220570 0.84 TSHR (0.35) TSHR
SCHEMBL18918251 0.83 HTR2A (0.37) TSHR
SCHEMBL9218213 0.83 GAA (0.32)
SCHEMBL9224823 0.82 TSHR (0.36) TSHR
SCHEMBL9219987 0.81 CHRNA7 (0.31)
SCHEMBL28263737 0.77 TSHR (0.41) TSHR
SCHEMBL9220265 0.77 TSHR (0.44) TSHR
SCHEMBL9226300 0.76 TSHR (0.40) TSHR
SCHEMBL31433296 0.75 MTNR1A (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5118879-A Used in the synthesis of medicinal and agricultural chemicals and water- and oil-repellent agents NIPPON OIL AND FATS CO., LTD. (JP) 1992-06-02 US claimed
EP-0420987-A1 Process for preparing fluoroalkyl derivatives NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1991-04-10 EP claimed
EP-0420987-B1 Process for preparing fluoroalkyl derivatives NIPPON OILS & FATS CO LTD (JP) 1995-05-03 EP disclosed
US-5118879-A Used in the synthesis of medicinal and agricultural chemicals and water- and oil-repellent agents NIPPON OIL AND FATS CO., LTD. (JP) 1992-06-02 US disclosed
EP-0420987-A1 Process for preparing fluoroalkyl derivatives NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1991-04-10 EP disclosed