Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.66 |
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | CCR6 | P51684 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11298577 | 0.88 | RAB9A (0.75) | RAB9AALDH1A1GAANPC1SMN1; SMN2 | |
| SCHEMBL11414330 | 0.83 | GAA (0.70) | RAB9AALDH1A1GAASMN1; SMN2CCR6 | |
| SCHEMBL2680169 | 0.82 | ALDH1A1 (0.66) | RAB9AALDH1A1GAANPC1SMN1; SMN2 | |
| SCHEMBL11599578 | 0.82 | KMT2A (0.86) | RAB9AALDH1A1GAANPC1SMN1; SMN2 | |
| SCHEMBL2477798 | 0.81 | GAA (0.69) | RAB9AALDH1A1GAASMN1; SMN2POLB | |
| SCHEMBL400890 | 0.81 | RAB9A (0.77) | RAB9AALDH1A1GAANPC1SMN1; SMN2 | |
| SCHEMBL8719394 | 0.81 | RAB9A (0.66) | RAB9AALDH1A1GAANPC1SMN1; SMN2 | |
| SCHEMBL21978380 | 0.81 | ALDH1A1 (0.63) | RAB9AALDH1A1GAANPC1SMN1; SMN2 | |
| SCHEMBL31558731 | 0.80 | KMT2A (0.72) | RAB9AALDH1A1GAANPC1SMN1; SMN2 | |
| SCHEMBL14045090 | 0.80 | RAB9A (0.59) | RAB9AALDH1A1GAANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0495226-B1 | 3-Aryl-5-alkylthio-4H-1,2,4-triazoles for treatment of hyperreflexia due to spinal trauma | MERRELL DOW PHARMA (US) | 1995-10-11 | — | — | EP | disclosed |
| US-5260450-A | Anticonvulsants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-11-09 | — | — | US | disclosed |
| US-5158968-A | 3-aryl-5-alkylthio-4H-1,2,4-traizoles for treatment of hyperreflexia due to spinal trauma | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5143933-A | Anticonvulsants | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-01 | — | — | US | disclosed |
| EP-0495226-A2 | 3-Aryl-5-alkylthio-4H-1,2,4-triazoles for treatment of hyperreflexia due to spinal trauma | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-22 | — | — | EP | disclosed |
| WO-1989006125-A1 | 4-ARALKYL-5-SUBSTITUTED-1,2,4-TRIAZOLE-5-THIOLS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-07-13 | — | — | WO | disclosed |
| EP-0323737-A1 | 4-Aralkyl-5-substituted-1,2,4-triazole-5-thiols | SMITHKLINE BEECHAM CORPORATION (US) | 1989-07-12 | — | — | EP | disclosed |