Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.60 |
| ▸ | HTR1A | P08908 | 8/20 | 0.60 |
| ▸ | HTR7 | P34969 | 7/20 | 0.60 |
| ▸ | HTR6 | P50406 | 5/20 | 0.60 |
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.59 |
| ▸ | HRH1 | P35367 | 3/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.56 |
| ▸ | HTR2C | P28335 | 3/20 | 0.56 |
| ▸ | NOS3 | P29474 | 1/20 | 0.55 |
| ▸ | NOS1 | P29475 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9229789 | 0.80 | KCNH2 (0.60) | HTR1ADRD2KCNH2HRH3 | |
| SCHEMBL3580702 | 0.80 | HTR1A (0.68) | HTR2AHTR1AHTR7HTR6DRD2 | |
| SCHEMBL2027077 | 0.78 | DRD2 (0.69) | HTR2AHTR1AHTR7HTR6DRD2 | |
| SCHEMBL9229518 | 0.77 | HTR1A (0.60) | HTR2AHTR1AHTR7HTR6DRD2 | |
| Hydrochloric Acid SCHEMBL6708494 | 0.77 | DRD2 (0.67) | HTR2AHTR1AHTR7HTR6DRD2 | |
| SCHEMBL6637562 | 0.77 | DRD2 (0.61) | HTR2AHTR1ADRD2ADRA1AHRH1 | |
| SCHEMBL8961462 | 0.76 | HTR2A (0.73) | HTR2AHTR1AHTR7HTR6DRD2 | |
| SCHEMBL29746904 | 0.76 | HTR2A (0.73) | HTR2AHTR1AHTR7HTR6DRD2 | |
| SCHEMBL10615678 | 0.75 | HTR1A (0.47) | HTR2AHTR1AHTR7HTR6DRD2 | |
| SCHEMBL3265484 | 0.75 | HTR2A (0.60) | HTR2AHTR1ADRD2SLC6A4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544765-B1 | Piperazinyl derivatives with affinity for 5-HT receptors | NOVO NORDISK AS (DK) | 1995-08-02 | — | — | EP | disclosed |
| US-5246935-A | Cardiovascular and gastrointestinal | NOVO NORDISK A/S (DK) | 1993-09-21 | — | — | US | disclosed |
| EP-0544765-A1 | PIPERAZINYL DERIVATIVES. | NOVO NORDISK AS (DK) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992003426-A1 | PIPERAZINYL DERIVATIVES | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | disclosed |