Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.53 |
| ▸ | NPC1 | O15118 | 10/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.45 |
| ▸ | RELA | Q04206 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10223594 | 0.98 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL10222750 | 0.84 | MAPT (0.56) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL19733285 | 0.82 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL10222751 | 0.81 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL10172908 | 0.80 | MAPT (0.58) | RAB9ANPC1HPGDKDM4EALDH1A1 | |
| SCHEMBL22775841 | 0.79 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL2609446 | 0.79 | LMNA (0.56) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL20966351 | 0.79 | CHRNB2 (0.43) | RAB9ANPC1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL10187352 | 0.79 | CHRNB2 (0.43) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL4790659 | 0.79 | RAB9A (0.54) | RAB9ANPC1KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537300-B1 | Oxazolidinedione hypoglycemic and hypocholesterolemic agents | PFIZER (US) | 1995-04-26 | — | — | EP | disclosed |
| EP-0537300-A1 | OXA- AND THIAZOLIDINEDIONE HYPOGLYCEMIC AND HYPOCHOLESTEROLEMIC AGENTS. | PFIZER (US) | 1993-04-21 | — | — | EP | disclosed |
| WO-1991019704-A2 | OXA- AND THIAZOLIDINEDIONE HYPOGLYCEMIC AND HYPOCHOLESTEROLEMIC AGENTS | PFIZER INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5037842-A | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents | PFIZER INC. (US) | 1991-08-06 | — | — | US | disclosed |