Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11038736 | 0.90 | TSHR (0.53) | SMN1; SMN2MAPTTSHRCYP1A2CYP3A4 | |
| SCHEMBL6553048 | 0.87 | KMT2A (0.55) | HSD17B2SMN1; SMN2MAPTCYP1A2KMT2A | |
| SCHEMBL4807790 | 0.86 | HTR4 (0.46) | HSD17B2HSD11B1SMN1; SMN2MAPTTSHR | |
| SCHEMBL6553052 | 0.86 | MAPT (0.46) | SMN1; SMN2MAPTTSHRCYP1A2CYP3A4 | |
| SCHEMBL4809444 | 0.83 | ALDH1A1 (0.56) | HSD11B1SMN1; SMN2MAPTCYP3A4KDM4E | |
| SCHEMBL9228976 | 0.82 | MAPT (0.38) | HSD17B2SMN1; SMN2MAPTTSHRCYP1A2 | |
| SCHEMBL4510376 | 0.81 | G6PD (0.51) | HSD17B2SMN1; SMN2MAPTTSHRCYP1A2 | |
| SCHEMBL1231155 | 0.81 | ALDH1A1 (0.46) | SMN1; SMN2MAPTKMT2APOLB | |
| SCHEMBL3867866 | 0.81 | ALDH1A1 (0.45) | SMN1; SMN2MAPTKMT2AKDM4EPOLB | |
| SCHEMBL29644945 | 0.80 | KMT2A (0.37) | SMN1; SMN2TSHRMAPK1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5399714-A | Process for the preparation of substituted indoles | CIBA-GEIGY CORPORATION (US) | 1995-03-21 | — | — | US | disclosed |
| US-5359083-A | Process for the preparation of substituted indoles | CIBA-GEIGY CORPORATION (US) | 1994-10-25 | — | — | US | disclosed |
| US-5248693-A | Antiallergens, antiinflammatory agents | CIBA-GEIGY CORPORATION (US) | 1993-09-28 | — | — | US | disclosed |