SCHEMBL4510376

SCHEMBL4510376

COc1cc(C(=O)ON2C(=O)CCC2=O)ccc1N1C(=O)C=CC1=O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
G6PD P11413 1/20 0.51
TLR9 Q9NR96 1/20 0.51
MGLL Q99685 1/20 0.44
MAPT P10636 3/20 0.42
ALDH1A1 P00352 2/20 0.42
HSP90AA1 P07900 2/20 0.42
CACNA1B Q00975 2/20 0.42
APBA1 Q02410 2/20 0.42
NPSR1 Q6W5P4 2/20 0.42
PKM P14618 1/20 0.42
MAPK1 P28482 1/20 0.42
RAB9A P51151 1/20 0.42
CCR6 P51684 1/20 0.42
APOBEC3G Q9HC16 1/20 0.42
KMT2A Q03164 4/20 0.41
LMNA P02545 1/20 0.37
TUBB4A P04350 2/20 0.36
TUBB P07437 2/20 0.36
TUBA3C P0DPH7 2/20 0.36
TUBA1B P68363 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4508271 0.90 MGLL (0.44) G6PDTLR9MGLLMAPTALDH1A1
SCHEMBL17301093 0.85 KMT2A (0.38) G6PDTLR9ALDH1A1HSP90AA1CACNA1B
SCHEMBL11038736 0.83 TSHR (0.53) MAPTALDH1A1MAPK1RAB9AKMT2A
SCHEMBL9225912 0.81 HSD17B2 (0.42) MAPTMAPK1KMT2ATSHRKDM4E
SCHEMBL6553048 0.80 KMT2A (0.55) MAPTALDH1A1HSP90AA1RAB9AKMT2A
SCHEMBL4807790 0.79 HTR4 (0.46) MAPTALDH1A1RAB9ALMNATUBB4A
SCHEMBL6553052 0.79 MAPT (0.46) MAPTALDH1A1MAPK1RAB9AKMT2A
SCHEMBL4520450 0.79 ALDH1A1 (0.34) G6PDTLR9MAPTALDH1A1HSP90AA1
SCHEMBL24939679 0.78 G6PD (0.62) G6PDTLR9MGLLMAPTALDH1A1
SCHEMBL4809444 0.76 ALDH1A1 (0.56) MAPTALDH1A1NPSR1RAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090305264-A1 COOPERATIVE PROBES AND METHODS OF USING THEM FLUIDIGM CORPORATION 2009-12-10 US disclosed
EP-2004861-A2 COOPERATIVE PROBES AND METHODS OF USING THEM Arcxis Biotechnologies, Inc. (US) 2008-12-24 EP disclosed
EP-1893741-A1 CELL-BASED MICROARRAYS, AND METHODS FOR THEIR PREPARATION AND USE Beckman Coulter, Inc. (US) 2008-03-05 EP disclosed
WO-2007114986-A2 COOPERATIVE PROBES AND METHODS OF USING THEM ARCXIS BIOTECHNOLOGIES, INC. (US) 2007-10-11 WO disclosed
WO-2007001817-A1 CELL-BASED MICROARRAYS, AND METHODS FOR THEIR PREPARATION AND USE BECKMAN COULTER, INC. (US) 2007-01-04 WO disclosed
US-20060292559-A1 Cell-based microarrays, and methods for their preparation and use BECKMAN COULTER, INC. (US) 2006-12-28 US disclosed
EP-0779934-B1 COMPOSITIONS AND METHODS FOR USE IN DETECTION OF ANALYTES BECKMAN COULTER INC (US) 2000-04-05 EP disclosed
US-5648213-A IMMUNOASSAY BECKMAN INSTRUMENTS, INC. (US) 1997-07-15 US disclosed
EP-0779934-A1 COMPOSITIONS AND METHODS FOR USE IN DETECTION OF ANALYTES BECKMAN INSTRUMENTS, INC. (US) 1997-06-25 EP disclosed
WO-1996006948-A1 COMPOSITIONS AND METHODS FOR USE IN DETECTION OF ANALYTES BECKMAN INSTRUMENTS, INC. (US) 1996-03-07 WO disclosed