Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 3/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9697197 | 0.79 | PSMD14 (0.34) | KDM4EMEN1KMT2APDE10APOLB | |
| SCHEMBL2163311 | 0.79 | MAPT (0.40) | MEN1KMT2APOLBMAPTMAPK1 | |
| SCHEMBL10634828 | 0.77 | GRIN2B (0.50) | KDM4EMEN1KMT2APDE10AMAPT | |
| SCHEMBL3258402 | 0.77 | MGAM (0.45) | ALDH1A1 | |
| SCHEMBL4633990 | 0.77 | CHEK1 (0.50) | KDM4EMEN1KMT2APDE10APOLB | |
| SCHEMBL5182911 | 0.77 | CNR2 (0.45) | GRIN1GRIN2B | |
| SCHEMBL7876698 | 0.76 | RAB9A (0.56) | KDM4EMEN1KMT2APOLBMAPT | |
| SCHEMBL463268 | 0.76 | DDAH1 (0.59) | MEN1KMT2APOLBDDAH1MAPT | |
| SCHEMBL4366276 | 0.75 | KMT2A (0.44) | KDM4EMEN1KMT2APDE10APOLB | |
| SCHEMBL7564203 | 0.75 | HTR6 (0.44) | RAB9ANPC1ALDH1A1GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527815-A | TREATMENT OF HYPERTENSION, CONGESTIVE HEART FAILURE, AND HIGH INTRAOCULAR PRESSURE | KOTOBUKI SEIYAKU CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |