Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9242423 | 0.93 | PSEN1 (0.45) | TDP1LMNAL3MBTL1CCR2ALDH1A1 | |
| SCHEMBL9239665 | 0.90 | TDP1 (0.48) | TDP1LMNAL3MBTL1CCR2ALDH1A1 | |
| SCHEMBL9237671 | 0.86 | LMNA (0.50) | TDP1LMNAL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL9241443 | 0.86 | CCR2 (0.45) | TDP1LMNAL3MBTL1CCR2TP53 | |
| SCHEMBL9242465 | 0.82 | TDP1 (0.45) | TDP1LMNAL3MBTL1CCR2ALDH1A1 | |
| SCHEMBL2484224 | 0.82 | LMNA (0.52) | TDP1LMNAL3MBTL1CCR2ALDH1A1 | |
| SCHEMBL6172815 | 0.81 | KMT2A (0.49) | LMNACCR2ALDH1A1TP53MAPT | |
| SCHEMBL9239997 | 0.80 | TDP1 (0.42) | TDP1LMNAL3MBTL1CCR2ALDH1A1 | |
| SCHEMBL8688921 | 0.80 | KDM4E (0.52) | TDP1LMNAL3MBTL1CCR2ALDH1A1 | |
| SCHEMBL9239380 | 0.79 | CCR2 (0.44) | TDP1CCR2ALDH1A1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639573-A1 | Benzocondensed five membered heterocycles, process of their preparation, their use as drug, as diagnostic means and pharmaceuticals containing it | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-02-22 | — | — | EP | disclosed |