SCHEMBL9237602

SCHEMBL9237602

Cc1cccc(C)c1C1=C(c2ccccc2)C(=O)NC1=O

nearest known ligand 0.54

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 6/20 0.54
GSK3B P49841 8/20 0.47
RET P07949 1/20 0.47
FGFR1 P11362 1/20 0.43
FGFR2 P21802 1/20 0.43
FGFR4 P22455 1/20 0.43
FGFR3 P22607 1/20 0.43
FABP4 P15090 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28552958 0.88 DAO (0.45) PTGS2GSK3BRET
SCHEMBL114611 0.82 PTGS2 (0.67) PTGS2GSK3B
SCHEMBL3816928 0.81 PTGS2 (0.50) PTGS2GSK3BFGFR1FGFR2FGFR4
SCHEMBL9474080 0.80 PTGS2 (0.64) PTGS2GSK3B
SCHEMBL3673282 0.79 DAO (0.41) PTGS2GSK3BRET
SCHEMBL3815134 0.79 PTGS2 (0.65) PTGS2GSK3B
SCHEMBL18049424 0.78 PTGS2 (0.57) PTGS2GSK3B
SCHEMBL94149 0.76 GSK3B (0.58) PTGS2GSK3B
SCHEMBL18049433 0.74 PTGS2 (0.57) PTGS2GSK3B
SCHEMBL15797114 0.74 PRKCB (0.54) PTGS2GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0628578-A3 2,6-Dimethylphenylphenymaleimide as comonomer in the copolymerisation of styrene or vinyl chlorid. CHEMIE LINZ GMBH (AT) 1995-09-27 EP disclosed
EP-0628578-A2 2,6-Dimethylphenylphenymaleimide as comonomer in the copolymerisation of styrene or vinyl chlorid DSM Chemie Linz GmbH (AT) 1994-12-14 EP disclosed