Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 6/20 | 0.40 |
| ▸ | DRD4 | P21917 | 6/20 | 0.40 |
| ▸ | DRD3 | P35462 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7892665 | 0.85 | ALDH1A1 (0.48) | HTTSMN1; SMN2LMNADRD2DRD4 | |
| SCHEMBL9299695 | 0.85 | LTA4H (0.40) | HTTSMN1; SMN2DRD2DRD4DRD3 | |
| SCHEMBL4605693 | 0.82 | ALDH1A1 (0.46) | ALDH1A1GAARAB9A | |
| SCHEMBL9418015 | 0.82 | ALDH1A1 (0.46) | ALDH1A1GAARAB9A | |
| SCHEMBL9418021 | 0.82 | ALDH1A1 (0.46) | ALDH1A1GAARAB9A | |
| SCHEMBL12095500 | 0.80 | CA12 (0.53) | HTTSMN1; SMN2LMNADRD2DRD4 | |
| SCHEMBL9237689 | 0.78 | ALDH1A1 (0.43) | HTTSMN1; SMN2LMNADRD2DRD4 | |
| SCHEMBL64191 | 0.78 | HTT (0.43) | HTTSMN1; SMN2LMNAALDH1A1AR | |
| SCHEMBL10492043 | 0.77 | MMP2 (0.45) | HTTSMN1; SMN2LMNAALDH1A1GAA | |
| SCHEMBL10680738 | 0.76 | CA12 (0.48) | HTTSMN1; SMN2LMNAALDH1A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5468890-A | Iodonium salts and process for the preparation thereof | WACKER-CHEMIE GMBH (DE) | 1995-11-21 | — | — | US | disclosed |