Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14131257 | 0.77 | LMNA (0.31) | — | |
| SCHEMBL14131229 | 0.75 | LMNA (0.32) | — | |
| SCHEMBL10337202 | 0.70 | LPAR3 (0.39) | — | |
| SCHEMBL3127470 | 0.67 | TSHR (0.42) | HRH3 | |
| SCHEMBL28724717 | 0.67 | — | — | |
| SCHEMBL13896820 | 0.66 | KMT2A (0.41) | HRH3 | |
| SCHEMBL19285576 | 0.66 | — | — | |
| SCHEMBL9697575 | 0.66 | LMNA (0.34) | — | |
| SCHEMBL528149 | 0.65 | LTA4H (0.41) | — | |
| SCHEMBL3170042 | 0.65 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507499-B2 | Substituted indole/indazole-pyrimidinyl compounds | CONFLUENCE LIFE SCIENCES, INC. (US) | 2013-08-13 | — | — | US | disclosed |
| WO-2012078674-A1 | SUBSTITUTED INDOLE/INDAZOLE-PYRIMIDINYL COMPOUNDS | CONFLUENCE LIFE SCIENCES, INC. (US) | 2012-06-14 | — | — | WO | disclosed |
| US-20120142696-A1 | SUBSTITUTED INDOLE/INDAZOLE-PYRIMIDINYL COMPOUNDS | ACLARIS THERAPEUTICS, INC. | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142696-A1 | SUBSTITUTED INDOLE/INDAZOLE-PYRIMIDINYL COMPOUNDS | MAPK1, MAP3K1, MAP3K20 | HRH3 685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.